Hydrophobic effect on the protein-ligand interaction; Hydrophobic field-effect index and hydrophobic correlation index.
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چکیده
منابع مشابه
Effect of ions on the hydrophobic interaction between two plates.
We use molecular dynamics simulations to investigate the solvent mediated attraction and drying between two nanoscale hydrophobic surfaces in aqueous salt solutions. We study these effects as a function of the ionic charge density, that is, the ionic charge per unit ionic volume, while keeping the ionic diameter fixed. The attraction is expressed by a negative change in the free energy as the p...
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Understanding the variation of nanofluidic behavior in the presence of an external electric field is critical for controlling and designing nanofluidic devices. By studying the critical infiltration pressure of liquids into hydrophobic nanopores using molecular dynamics (MD) simulations and experiments, important insights can be gained on the variation of the effective liquid-solid interfacial ...
متن کاملDigital coding of amino acids based on hydrophobic index.
Analysis of amino acid sequences can provide useful insights into the tertiary structures of proteins and their biological functions. One of the critical problems in amino acid analysis is how to establish a digital coding system to better reflect the properties of amino acids and their degeneracy. Based on the hydrophobic index, a one-to-one relationship has been established between the amino ...
متن کاملHydrophobic Interaction Chromatography
modeling for the design of a Biomimetic chimeric ligand. Application to the puriRcation of bovine heart L-lactate dehydrogenase. Biotechnology and Bioengineering 63: 321}331. Lowe CR (1984) Applications of reactive dyes in biotechnology. In: Wiseman A (ed.) Topics in Enzyme and Fermentation Biotechnology, vol. 9. Chichester: Ellis Horwood. Lowe CR, Burton S, Pearson J, Clonis YD and Stead CV (1...
متن کاملHydrophobic Interaction Chromatography.
Most proteins and large polypeptides have hydrophobic regions at their surface. These hydrophobic "patches" are due to the presence of the side chains of hydrophobic or nonpolar amino acids such as phenylalanine, tryptophan, alanine, and methionine. These surface hydrophobic regions are interspersed between more hydrophilic or polar regions and the number, size, and distribution of them is a sp...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1989
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.37.86